The Structure Theory -

1-Pan-Evolutionary theory - Category theory and graph theory-network topology, the PVED mechanism of space-time organization, Assembly theory and artificial evolution.
2-Geoculturology and cities groups patterns - the Era of 4 Axes and the Theory of 4 Worlds, a historical perspective vision of the planet from Egyptian Middle Kingdom to the future Space Eco-cities:
a-Spiritual world of the Axial age, b-Knowledge world of the Silk road, c-Natural world of the Scientific exploration, d-Machine world of the Space age.

Methodological shift - From psychology and logical debate to natural observation and historical practice, the combination of linguistic analysis and operational technology, in astronomical physics and medical biology, forming the development path of science.
Complexity theory - 1952, PW.Anderson spontaneous symmetry breaking, AM.Turing morphogenesis, 1963-1964, EN.Lorenz equations, M.Gell-Mann and G.Zweig quark model.

Design and Assembly of Engineered Cells
- Micro-Fluidic Chips, integration of molecular and cellular biotechnology.
Biomanufacturing - Industrial transformation of synthetic biology, standardized design of engineered cells, and industrial-scale synthesis.
Target market - Precision medicine and cell therapy, natural pharmaceutical molecule idenfication and metabolic engineering biosynthesis.

Systems genetics - (1) Cell models and engineered cells.
Cell communication and molecular network topology analysis, Homology search and computer-aided design, Molecular modules and genes assembly and synthesis.
Systems pharmacology - (2) Drug analysis and molecular screening.
Pharmacognosy and network pharmacology analysis, Cellular kinetic analysis, Internet media and databases - Biological and genetic resources.
Cell factory - (3) Fermentation process and purification technology.
Chassis cells and selection - establishment of cell lines, Cell bank - Molecular markers of cell atlas, Standardized industrial production process.

Systems Medicine - Bj.Zeng's Exploration:

1991-1999, a-Systems bioengineering and genetics - Bio-systems science and engineering;
b-Artificial biological system Design - Transgenic oviduct and cell biomimetic engineering;
c-Artificial intelligence and genetic engineering - Computational bioinformatics, experimental biotechnology and nano-bioelectronics.

2007-2010, Systems dynamics of cytogenesis - Cellular-neuron computers, and organic robots.
2023-2025, Synthetic neurogenetics - Alternative consciousness and human-machine co-evolution.

Note:

From C.Bernard's experimental medicine, molecular and structural biology to systems medicine, synthetic and systems Biology (coupled) - during 1996-1999, organization of international conferences and associates, citing relevant literature in 1910 and 1968.
After 2014, the international community expanded the methodology to the DBTL cycle mode.